ea0056gp35 | Adrenal cortex | ECE2018
Venneri Mary Anna
, Hasenmajer Valeria
, Fiore Daniela
, Sbardella Emilia
, Pofi Riccardo
, Graziadio Chiara
, Gianfrilli Daniele
, Pivonello Claudia
, Negri Mariarosaria
, Naro Fabio
, Grossman Ashley B
, Lenzi Andrea
, Pivonello Rosario
, Isidori Andrea M
Introduction: Adrenal insufficiency requires life-long glucocorticoid replacement. Conventional therapies fail to mimic endogenous cortisol circadian rhythm. Clock genes are essential components of the molecular machinery controlling organs circadian function and are influenced by glucocorticoids. However, clock genes expression has never been investigated in patients with adrenal insufficiency (AI).Aim: To evaluate the effect of the timing of gluc...